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Vol.44, No.6, 418 ~ 424, 2006
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| Title |
| Special Edition : Symposium on Nano and Biomaterials ; The Effects of Bio-ceramic Al2O3 Particles on the Proliferation of Osteoblast and Osteoclast |
| 송호연 Ho Yeon Song , 김영희 Young Hee Kim , 고광균 Kwang Kjune Ko , 김양희 Yang Hee Kim , 오익현 Ik Hyun Oh , 이병택 Byong Taek Lee |
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| Abstract |
| The main cause of re-operation in patients who received total hip arthroplasty is wear debris-mediated osteolysis in bone-implant interface. Recently, alumina or zirconia ceramic hip joint have also become available. Therefore, Al2O3 particles induced cytotoxicity on osteoblast-like MG-63 cells and osteoclastlike Raw 264.7 cells was observed through in vitro and in vivo study. Low concentration of Al2O3 powders did not induce cytotoxicity, however the proliferation of osteoblast cultured with high concentration of Al2O3 powders were significantly inhibited. Al2O3 particles were also observed on the surface and inside the MG-63 and Raw 264.7 cells accompanied with the morphological changes of cytoplasmic organelles. Al2O3 particles injected in subcutaneous tissue of rats did not induce inflammatory response. |
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| Key Words |
| Al2O3 Particle, Osteoblast, Osteoclast, Viability, Morphologic change |
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