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Vol.44, No.6, 412 ~ 418, 2006
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| Title |
| Special Edition : Symposium on Nano and Biomaterials ; Antimicrobial Mechanisms of Silver Nano-particles and Their In vivo Study for Antibiotic Alternative |
| 송호연 Ho Yeon Song , 김영희 Young Hee Kim , 고광균 Kwang Kjune Ko , 오익현 Ik Hyun Oh , 이병택 Byong Taek Lee |
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| Abstract |
| Silver is one of the most universal antimicrobial substances. Nano-technogy enables us to expand the surface area of silver particles markedly. Silver nano-particles were successfully produced less than 10 nm in size. Nanosilver showed excellent antibacterial activities against Salmonella typhi and Pseudomonas aeruginosa around 1 ppm and Mycobacterium tuberculosis around 10 ppm. Nanosilver induced the severe morphologic changes in cell wall and cytoplasm of bacteria. Antimicrobial mechanisms of nanosilver were different according to the species of bacteria; plasmolysis in Salmonella typhi and metabolic disturbance due to ingestion of nanosilver in M. tuberculosis. To confirm the toxicity of nanosilver, four groups of mice (60 mice in total) have been fed with nanosilver suspension (0, 10, 30, 100 ppm) for 6 months. Their behaviors, weight changes and hematologic findings of mice after feeding of nanosilver showed similar results with those of the control although the mice had been fed 100 ppm of nanosilver for 6 months. From the results, silver nanoparticles probably will be available as a good and safe antibiotic alternative. |
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| Key Words |
| Nanosilver, Antimicrobial mechanism, In vivo study |
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