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Vol.44, No.6, 381 ~ 386, 2006
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| Title |
| Special Edition : Symposium on Nano and Biomaterials ; Fabrication and Assessment of Hydroxyapatite/Poly ε-caprolactone Composite Scaffolds |
| 현용택 Yong Taek Hyun , 김승언 Seung Eon Kim , 허수진 Su Jin Heo , 신정욱 Jung Woog Shin , 이향미 Hyang Mi Lee , 윤석영 Seog Young Yoon |
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| Abstract |
| Porous and bioactive composite scaffolds were successfully fabricated by salt leaching method using poly ε-caprolactone (PCL) and hydroxyapatite (HA). The scaffolds have interconnected pore structure with pore size ranging from 200 to 230 ㎛. The pore size of pure PCL scaffolds and PCL/HA scaffolds was similar to that of the salt particles (200-300 ㎛). However, the porosity and the pore size of the PCL/HA composite scaffolds slightly decreased as the HA concentration increased. In addition, the pore walls became thick and the small pores decreased, and consequently the interconnectivity of the pores decreased. The cell viability and response of the scaffolds were assessed by MTT assay. The biological assessment results showed that HA content did not affect initial cell attachment in both scaffolds with and without HA. The osteoblasts proliferated in both types of the scaffolds, but the cell number was higher in the PCL/HA composite scaffolds. It was clearly demonstrated that the incorporation of hydroxyapatite enhances bone cell proliferation rather than initial cell attachment in PCL/HA composite scaffolds. Combining HA and biodegradable polymer could be applicable to bone scaffolding materials. |
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| Key Words |
| Scaffold, Hydroxyapatite, Cell proliferation, Biodegradable polymer, Osteoblast |
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