ISML-ITMT(Institute Sperimentleder Metalli Leggeri-Intermediate Themomechanical Treatment) increases greatly fracture toughness of 7475 aluminum alloy. The ISML-ITMT samples have shown fine microstructure with small volume fraction of coarse particles, hence small number and large spacings of particles. This distribution of coarse secondary particles contributed to increasing the fracture toughness. The larger the spacing of intermediate particles in ITMT samples is, the higher the toughness is. The dimple spacing of the fractured surfaces was almost the same as the coarse particle spacing, suggesting that the coarse particles act as nucleation sites of micro-voids. Grain refinement does not seem to contribute to increasing the toughness. The most important parameter for increasing the fracture toughness is the distribution of coarse particles rather than the grain size.