A 7050 high strength aluminum alloy was processed by three different methods to obtain the microstructures containing a large amount of deformed grains and the ones containing considerable amount of subgrains and recrystallized grains, respectively. The differences of the microstructure before and after T6 temper were investigated by optical and electron microscopes, and the average stress corrosion crack velocity vs. the stress intensity factor was measured by precracked CT specimens. The effect of the grain characteristics on the stress corrosion cracking susceptibility was more pronounced before T6 temper than after T6 temper. The resistance of the materials containing deformed grains and subgrains to stress corrosion cracking was superior to that of the materials containing recrystallized grains. The stress corrosion cracking susceptibility depended largely on the behavior of grain-boundary precipitates.